Long noncoding RNA linc00462 promotes hepatocellular carcinoma progression - 08/08/17

Doi : 10.1016/j.biopha.2017.06.004

JianDe Gong ^a, XuFei Qi ^a, Yi Zhang ^a, YingCong Yu ^b, XiZhou Lin ^b, HongLiang Li ^a,^⁎ , YiRen Hu ^c,^d,^⁎
^a Department of Gastroenterology, Yinzhou People’s Hospital, Ningbo, Zhejiang, China
^b Department of Gastroenterology, Wenzhou No. 3 Clinical Institute of Wenzhou Medical University, Wenzhou People’s Hospital, Wenzhou, Zhejiang, China
^c Medical College of Soochow University, Suzhou, Jiangsu, China
^d Department of General Surgery, Wenzhou No. 3 Clinical Institute of Wenzhou Medical University, Wenzhou People’s Hospital, Wenzhou, Zhejiang, China

^⁎Corresponding author at: Department of Gastroenterology, Yinzhou People’s Hospital, No. 251 Baizhang East Road, Yinzhou District, Ningbo, Zhejiang 315000, China.Department of GastroenterologyYinzhou People’s HospitalNingboZhejiangChina^⁎⁎Corresponding author at: Department of General Surgery, Wenzhou No. 3 Clinical Institute of Wenzhou Medical University, Wenzhou People’s Hospital, Wenzhou, Zhejiang 325000, China.Department of General SurgeryWenzhou No. 3 Clinical Institute of Wenzhou Medical UniversityWenzhou People’s HospitalWenzhouZhejiangChina

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Abstract

Background

Hepatocellular carcinoma (HCC) represents one of the most common malignancies worldwide. In two pubic long noncoding RNA (lncRNA) profiling studies of HCC, linc00462 was consistently upregulated. We analyzed the clinical significance and biological role of linc00462 in HCC.

Methods

We performed quantitative real-time PCR analysis to determine the levels of linc00462 in HCC tissues from 49 patients. Functional analysis was performed in cell lines and in an animal model to support clinical findings.

Results

Our data showed that linc00462 was significantly upregulated in HCC tissues compared with matched normal tissues. The knockdown of linc00462 in HCC cells resulted in a much less aggressive oncogenic phenotype, and linc00462 downregulation contribute to the inactivation of the PI3K/AKT signaling pathway.

Conclusions

linc00462 may be a potential therapeutic target in HCC.

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Keywords : Hepatocellular carcinoma, Long noncoding RNA, linc00462, Proliferation, Invasion

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Vol 93

P. 40-47 - septembre 2017 Retour au numéro

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Long noncoding RNA linc00462 promotes hepatocellular carcinoma progression - 08/08/17

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