Dilantin digital defects - 06/10/17
Résumé |
Diphenylhydantoin (phenytoin) is a widely used drug with multiple adverse effects, several of them cutaneous. Prenatal exposure to hydantoins may result in a spectrum of structural, developmental, and behavioral changes known as the fetal hydantoin syndrome (FHS). A patient with the dysmorphic characteristics of FHS had unusual hyperpigmentation of several fingernails, a finding which has not been described in other patients with FHS. We propose a mechanism for the dysmorphic action of phenytoin on the developing fetus, consonant with the known effects of hydantoins on collagen metabolism.
Le texte complet de cet article est disponible en PDF. Supported in part by Grant 2 R01 AM-17253 from the National Institutes of Health. |
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Publication No. 98 from the Der~natological Research Laboratories of Duke University Medical Center. |
Vol 5 - N° 2
P. 191-196 - août 1981 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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