Evidence for eosinophil degranulation with deposition of granule major basic protein in solar urticaria - 06/10/17
Abstract |
Multiple sequential biopsy specimens of wheals elicited by a solar simulator in four patients with severe solar urticaria were studied with the use of indirect immunofluorescence for eosinophil granule major basic protein. Examination of control biopsy specimens from normal, unstimulated skin did not show eosinophils or major basic protein deposition. Five minutes after solar simulation, eosinophils were observed in vessels in the dermis, and 2 hours later there was marked tissue eosinophilia. Extracellular major basic protein was extensively deposited in the dermis at 2 and 24 hours, suggesting eosinophil degranulation. Thus evolution of the solar urticaria wheal is accompanied by infiltration of eosinophils and neutrophils and by tissue deposition of the eosinophil major basic protein, suggesting eosinophil degranulation.
Le texte complet de cet article est disponible en PDF. Supported in part by National Institutes of Health Grants Nos. AR 36008 and AI 15231, The Mayo Foundation, the Kieckhefer Foundation (Prescott, Ariz.), and the Eleanor Naylor Dana Charitable Trust. |
Vol 21 - N° 1
P. 75-80 - juillet 1989 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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