Fibrin and fibrinogen-related antigens in systemic sclerosis (scleroderma) - 06/10/17
Résumé |
Abnormalities in fibrin deposition are implicated in the pathogenesis of vascular occlusion in systemic sclerosis. We have used a technique that involves electrophoresis and densitometric analysis of captured fibrin- and fibrinogen-related antigens to measure the concentration of the individual fibrin and fibrinogen degradation products in 13 patients with systemic sclerosis and in 15 healthy control subjects. As a group, patients with systemic sclerosis had markedly elevated levels of total fibrin-related antigen (p = 0.0007) and D-dimer (p = 0.0004), the terminal degradation product of cross-linked fibrin. The levels of fibrin monomer, an intermediate product in the conversion of fibrinogen to cross-linked fibrin, and of D-monomer, a terminal breakdown fragment of fibrinogen and fibrin monomer, were also elevated (p < 0.005). We conclude that patients with systemic sclerosis have evidence of enhanced fibrin formation and degradation.
Le texte complet de cet article est disponible en PDF. Supported in part by grant AR 39658 from the National Institutes of Health (V.F.). |
Vol 25 - N° 5P1
P. 771-775 - novembre 1991 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?