Médecine

Paramédical

Autres domaines


S'abonner

Cyclosporine in psoriasis: A multicenter dose-finding study in severe plaque psoriasis - 06/10/17

Doi : 10.1016/0190-9622(92)70012-5 
Enno Christophers, MD a, , Ulrich Mrowietz, MD a, Hans-Heinrich Henneicke a, Lothar Färber, MD b, Dieter Welzel, MD b,  participants in the German multicenter study *
a From the Department of Dermatology, University of Kiel 
b Clinical Research Department, Sandoz AG, Nümberg. 

**Reprint requests: Prof. Dr. E. Christophers, Department of Dermatology, University of Kiel, Schittenhelmstr. 7, D-2300 Kiel 1, Germany.

Résumé

Interim results of a randomized, controlled, dose-finding study conducted in 24 dermatology centers on 217 patients with severe chronic plaque psoriasis (entry psoriasis area and severity index of at least 15) are presented. Patients were first treated with cyclosporine either 1.25 or 2.5 mg/kg/day (Sandimmune); in case of inadequate response the dosage was increased to a maximum of 5 mg/kg/day. Cyclosporine was given for 12 to 36 weeks. Treatment was classified as “successful” if the psoriasis area and severity index was reduced to 25% or less of the baseline value or below 8. At the end of the treatment period 18% of patients had improved their psoriasis area and severity index “successfully” with the initial dose of 1.25 mg/ kg/day. “Successful” improvement with the initial dose of 2.5 mg/kg/day was achieved in 56% of the cases. In the 1.25 mg group, 44 patients had to increase their dose to 2.5 mg/kg/ day and 31 patients to 5 mg/kg/day. In 29 patients whose dosages were started at 2.5 mg/ kg/day the dosage was subsequently increased to 5 mg/kg/day. Although 1.25 mg/kg/day proved to be effective in some cases, 2.5 mg/kg/day of cyclosporine is the optimal starting dose. Adverse events were observed in 10% of the patients taking 1.25 mg/kg/day, in 20% taking 2.5 mg/kg/day, and in 32% taking 5 mg/kg/day. The most common were gastrointestinal complaints, followed by the common cold and other viral infections. An increase of serum creatinine level above 130 Amol/L occurred in five patients who could continue therapy after reducing the dose. Among those patients taking 1.25, 2.5, or 5 mg/kg/ day of cyclosporine, 16.2%,17.1%, and 17.8%, respectively, were withdrawn from the study. The reasons were lack of efficacy (8.1% to 11%) and noncompliance (1.6% to 4.5%). A total of 1.6% to 3.2% of the patients discontinued the study because of adverse events.

Le texte complet de cet article est disponible en PDF.

 Supported by Sandoz AG, Nürnberg.


© 1992  Publié par Elsevier Masson SAS.
Ajouter à ma bibliothèque Retirer de ma bibliothèque Imprimer
Export

    Export citations

  • Fichier

  • Contenu

Vol 26 - N° 1

P. 86-90 - janvier 1992 Retour au numéro
Article précédent Article précédent
  • Clinicopathologic spectrum of specific cutaneous lesions of disseminated coccidioidomycosis
  • Steven R. Quimby, Suzanne M. Connolly, R.K. Winkelmann, Jerry D. Smilack
| Article suivant Article suivant
  • Topical capsaicin for treatment of hemodialysis-related pruritus
  • Debra L. Breneman, J. Scott Cardone, Renee F. Blumsack, Ronald M. Lather, Edward A. Searle, Victor E. Pollack

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Déjà abonné à cette revue ?

;

Mon compte


Plateformes Elsevier Masson

Déclaration CNIL

EM-CONSULTE.COM est déclaré à la CNIL, déclaration n° 1286925.

En application de la loi nº78-17 du 6 janvier 1978 relative à l'informatique, aux fichiers et aux libertés, vous disposez des droits d'opposition (art.26 de la loi), d'accès (art.34 à 38 de la loi), et de rectification (art.36 de la loi) des données vous concernant. Ainsi, vous pouvez exiger que soient rectifiées, complétées, clarifiées, mises à jour ou effacées les informations vous concernant qui sont inexactes, incomplètes, équivoques, périmées ou dont la collecte ou l'utilisation ou la conservation est interdite.
Les informations personnelles concernant les visiteurs de notre site, y compris leur identité, sont confidentielles.
Le responsable du site s'engage sur l'honneur à respecter les conditions légales de confidentialité applicables en France et à ne pas divulguer ces informations à des tiers.