Topical capsaicin for treatment of hemodialysis-related pruritus - 06/10/17
Résumé |
Pruritus is a significant problem for many patients undergoing long-term hemodialysis. Topical capsaicin depletes and prevents the reaccumulation of substance P in peripheral sensory neurons. Substance P functions in the transmission of pain and probably itch sensations. An open-label, uncontrolled trial and a double-blind, vehicle-controlled trial were conducted to evaluate the efficacy and safety of capsaicin 0.025% cream in the treatment of localized areas of pruritus in patients undergoing long-term hemodialysis. Eight of nine evaluable, patients in the open-label trial reported marked relief or complete resolution of itching during the study period, and two of five evaluable patients in the double-blind trial reported complete resolution of itching in the capsaicin-treated arm with no or minimal improvement in the vehicletreated arm. Twelve patients in the open-label trial and two in the double blind trial were unevaluable. No serious treatment-related adverse reactions occurred.
Le texte complet de cet article est disponible en PDF.Vol 26 - N° 1
P. 91-94 - janvier 1992 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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