Women at risk of pregnancy who are taking potentially teratogenic drugs need to use highly effective contraception. The choice of contraception should reflect the woman's feelings about induced abortion as a backup in case of contraceptive failure. If abortion is acceptable, use of any contraceptive seems reasonable. If abortion is not acceptable, depomedroxyprogesterone acetate, oral contraceptives, and intrauterine devices (each used with a condom) should provide the greatest protection against pregnancy. For most young women, the contraceptive of choice will be a low-dose oral contraceptive.