Dermatitis due to members of the Compositae (Asteraceae) family of plants has been reported for many years from several parts of the world. Nevertheless, it seems to be overlooked by many present-day clinicians, undoubtedly because clinically it mimics photodermatitis or an airborne contact dermatitis of nonplant origin. This clinical review summarizes the rich literature on the subject, emphasizes the remarkably consistent clinical picture, and updates for readers relevant advances in botanical biochemistry and clinical implications, as well as current methods for diagnosis, attempts at treatment, and concepts of pathogenesis. It is hoped that the review will focus needed attention on this syndrome and will enhance prospects for accurate diagnosis, as well as further investigations into treatment and prevention.