Cutaneous type of adult T cell leukemia/lymphoma in a French West Indian woman : Clonal rearrangement of T-cell receptor β and γ genes and monoclonal integration of HTLV-I proviral DNA in the skin infiltrate - 12/10/17
Abstract |
A 45-year-old woman, a native of the French West Indies who had lived in France since 1973, developed multiple cutaneous plaques and nodules in 1987. Histopathologic studies revealed dermal infiltration with mature activated T cells (CD4+, CD25+, DR+) with nuclear convolutions and epidermatotropism. High titers of specific human T lymphotropic virus (HTLV)-I antibodies were detected in the serum. Molecular analysis of DNA extracted from the skin tumor biopsy specimen showed a clonal integration of an HTLV-I provirus and a T-cell clonal population as demonstrated by T-cell receptor β and γ gene rearrangement studies. Neither HTLV-I provirus nor T-cell receptor rearrangements were detected in peripheral blood mononuclear cells DNA despite the presence of rare adult T cell leukemia cells (< 1 %) and a small excess of DR-expressing cells, and detection of HTLV-I Pol and Px sequences by in vitro gene amplification. In this case only gene analysis of the skin lesions made possible an early diagnosis of a cutaneous adult T cell leukemia. This illustrates the need for such molecular studies to differentiate, in HTLV-I seropositive patients from endemic areas, a HTLV-I—induced T cell lymphoma from HTLV-I—nonrelated cutaneous T cell lymphomas.
Le texte complet de cet article est disponible en PDF.* | Supported in part by grants from Association pour la Recherche contre le Cancer (ARC) (contrat 6670) Programme National de recherche sur le SIDA et les rétro-virus humains (contract 060166) and from La Fondation contre la Leucémie. |
Vol 23 - N° 5P2
P. 994-1000 - novembre 1990 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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