Verrucous lesions secondary to DNA viruses in patients infected with the human immunodeficiency virus in association with increased factor XIIIa-positive dermal dendritic cells - 12/10/17
Résumé |
Background: Hyperkeratotic lesions caused by varicella-zoster, herpes simplex, or cytomegalovirus occur in patients infected with human immunodeficiency virus type 1 (HIV-1). We have also observed this type of lesion with molluscum contagiosum.
Objectives: These cases were studied to determine whether there are any pathologic changes unique to these lesions.
Methods: The cases were studied by routine microscopic examination and immunohis-tochemistry.
Results: Each case showed changes diagnostic of the viral infection, which was confirmed by immunohistochemical stains for herpes simplex and cytomegalovirus. In the dermis there were fewer inflammatory cells than expected, but there was an increase in factor XIIIa-pos-itive dendritic cells.
Conclusion: Varicella-zoster, herpes simplex virus, cytomegalovirus, and molluscum contagiosum can cause verrucous lesions in HIV- 1-infected patients. These lesions may be related to an increase in factor XIIIa-positive dendritic cells.
Le texte complet de cet article est disponible en PDF.| * | Supported in part by an interagency agreement from the National Institutes of Health (NIAMS Y01AR90008 and Y01AR00014). |
| ** | The opinions or assertions contained herein are the private views of the authors and are not to be considered as official or as reflecting the views of the Departments of the Army, Navy, or Defense. |
| *** | No reprints available. |
Vol 27 - N° 6P1
P. 943-950 - décembre 1992 Retour au numéro
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