Complement deposition in the skin of patients with herpes-associated erythema multiforme - 12/10/17
Abstract |
Granular staining for C3 by direct immunofluorescence is a frequent finding along the dermoepidermal junction and in papillary blood vessels in the early skin lesions of erythema multiforme. In order to evaluate whether the complement cascade is activated by the classical or alternative pathway, ten biopsies from patients with herpes-associated erythema multiforme, which were positive for granular C3 along the dermoepidermal junction, were stained by an immunofluorescence technic for other complement components. Staining for the components of classical pathway, C1q and C4, were found in none of the ten biopsies. However, in nine of ten biopsies, granular staining for properdin was present along the dermoepidermal junction. These findings suggest complement activation by the alternative complement pathway in herpes-associated erythema multiforme.
Le texte complet de cet article est disponible en PDF. †Supported by Grant AI 16637 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD. |
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*The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. |
Vol 9 - N° 2
P. 199-203 - août 1983 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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