Imatinib mesylate–induced repigmentation of vitiligo lesions in a patient with recurrent gastrointestinal stromal tumors - 01/11/17
Reprint requests: Yu-hong Wang, MD, PhD; No. 23 You-Zheng Street, The First Hospital of Harbin Medical University, Harbin, China, 150001.Abstract |
We report a case of vitiligo with localized repigmentation induced by imatinib mesylate. An elderly Chinese man has been characterized with recurrent gastrointestinal stromal tumors originated from interstitial cells of Cajal with gain-of-function c-kit mutation. His recurrent tumors have responded to imatinib mesylate therapy. To our surprise, his decade-long vitiligo was dramatically ameliorated by localized repigmentation, which is considered to be the side effect of imatinib mesylate. Hypopigmentation induced by imatinib mesylate with possible molecular blockage to a melanin-dependent KIT signal has been well documented; however, our case with repigmentation suggested that KIT signal of melanin formation would be much more sophisticated than we have believed.
Le texte complet de cet article est disponible en PDF.Abbreviations used : CML, GIST, MITF
Plan
| Supported by Heilongjiang Province Scientific Fund (No. WC05C04 and No. GC07C335) and the Academic Fund of the First Hospital of Harbin Medical University, China. |
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| Conflicts of interest: None declared. |
Vol 59 - N° 5S
P. S80-S83 - novembre 2008 Retour au numéro
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