S'abonner

A synopsis of brown adipose tissue imaging modalities for clinical research - 14/11/17

Doi : 10.1016/j.diabet.2017.03.008 
L. Sun a, 1, J. Yan b, c, 1, L. Sun d, S.S. Velan e, f, M.K.S. Leow a, f, g, h, i, j, k,
a Clinical Nutrition Research Centre (CNRC), Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR) and National University Health System, Singapore 
b Department of Nuclear Medicine, First Hospital of Shanxi Medical University, China 
c Molecular Imaging Precision Medicine Collaborative Innovation Center, Shanxi Medical University, China 
d Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore 
e Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, A*STAR, Singapore 
f Department of Medicine and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 
g Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 
h Office of Clinical Sciences, Duke-NUS Medical School, Singapore 
i Clinical Trials and Research Unit, Changi General Hospital, Singapore 
j Department of Medicine, National University Hospital, Singapore 
k Department of Endocrinology, Tan Tock Seng Hospital, Singapore, Singapore 

Corresponding author at: Centre for Translational Medicine, 14 Medical Drive #07-02, MD 6 Building, Yong Loo Lin School of Medicine, Singapore 117599, Singapore.Centre for Translational Medicine14 Medical Drive #07-02, MD 6 Building, Yong Loo Lin School of MedicineSingapore 117599Singapore

Bienvenue sur EM-consulte, la référence des professionnels de santé.
Article gratuit.

Connectez-vous pour en bénéficier!

Abstract

Body weight gain results from a chronic excess of energy intake over energy expenditure. Accentuating endogenous energy expenditure has been accorded considerable attention ever since the presence of brown adipose tissue (BAT) in adult humans was recognized, given that BAT is known to increase energy expenditure via thermogenesis. Besides classic BAT, significant strides in our understanding of inducible brown adipocytes have been made regarding its development and function. While it is ideal to study BAT histologically, its relatively inaccessible anatomical locations and the inherent risks associated with biopsy preclude invasive techniques to evaluate BAT on a routine basis. Thus, there has been a surge in interest to employ non-invasive methods to examine BAT. The gold standard of non-invasive detection of BAT activation is 18F-fluorodeoxyglucose positron emission tomography (PET) with computed tomography (CT). However, a major limitation of PET/CT as a tool for human BAT studies is the clinically significant doses of ionizing radiation. More recently, several other imaging methods, including single-photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), infrared thermography (IRT)/thermal imaging and contrast ultrasonography (US) have been developed in hopes that they would allow non-invasive, quantitative measures of BAT mass and activity with lower costs. This review focuses on such methods to detect human BAT activation and white adipose tissue (WAT) browning to prompt the establishment of BAT-centric strategies for augmenting energy expenditure and combatting obesity. Clinical validation of these methods will most likely expand the scope and flexibility of future BAT studies.

Le texte complet de cet article est disponible en PDF.

Keywords : Brown adipose tissue, Clinical imaging, Non-invasive, Obesity


Plan


© 2017  Elsevier Masson SAS. Tous droits réservés.
Ajouter à ma bibliothèque Retirer de ma bibliothèque Imprimer
Export

    Export citations

  • Fichier

  • Contenu

Vol 43 - N° 5

P. 401-410 - octobre 2017 Retour au numéro

Bienvenue sur EM-consulte, la référence des professionnels de santé.

Mon compte


Plateformes Elsevier Masson

Déclaration CNIL

EM-CONSULTE.COM est déclaré à la CNIL, déclaration n° 1286925.

En application de la loi nº78-17 du 6 janvier 1978 relative à l'informatique, aux fichiers et aux libertés, vous disposez des droits d'opposition (art.26 de la loi), d'accès (art.34 à 38 de la loi), et de rectification (art.36 de la loi) des données vous concernant. Ainsi, vous pouvez exiger que soient rectifiées, complétées, clarifiées, mises à jour ou effacées les informations vous concernant qui sont inexactes, incomplètes, équivoques, périmées ou dont la collecte ou l'utilisation ou la conservation est interdite.
Les informations personnelles concernant les visiteurs de notre site, y compris leur identité, sont confidentielles.
Le responsable du site s'engage sur l'honneur à respecter les conditions légales de confidentialité applicables en France et à ne pas divulguer ces informations à des tiers.


Tout le contenu de ce site: Copyright © 2024 Elsevier, ses concédants de licence et ses contributeurs. Tout les droits sont réservés, y compris ceux relatifs à l'exploration de textes et de données, a la formation en IA et aux technologies similaires. Pour tout contenu en libre accès, les conditions de licence Creative Commons s'appliquent.