Age-induced and photoinduced changes in gene expression profiles in facial skin of Caucasian females across 6 decades of age - 13/12/17
Abstract |
Background |
Intrinsic and extrinsic factors, including ultraviolet irradiation, lead to visible signs of skin aging.
Objective |
We evaluated molecular changes occurring in photoexposed and photoprotected skin of white women 20 to 74 years of age, some of whom appeared substantially younger than their chronologic age.
Methods |
Histologic and transcriptomics profiling were conducted on skin biopsy samples of photoexposed (face and dorsal forearm) or photoprotected (buttocks) body sites from 158 women. 23andMe genotyping determined genetic ancestry.
Results |
Gene expression and ontologic analysis revealed progressive changes from the 20s to the 70s in pathways related to oxidative stress, energy metabolism, senescence, and epidermal barrier; these changes were accelerated in the 60s and 70s. The gene expression patterns from the subset of women who were younger-appearing were similar to those in women who were actually younger.
Limitations |
Broader application of these findings (eg, across races and Fitzpatrick skin types) will require further studies.
Conclusions |
This study demonstrates a wide range of molecular processes in skin affected by aging, providing relevant targets for improving the condition of aging skin at different life stages and defining a molecular pattern of epidermal gene expression in women who appear younger than their chronologic age.
Le texte complet de cet article est disponible en PDF.Key words : aging, facial skin appearance, gene expression, genetics, intrinsic aging, photoaging, photoprotection, pigmentation, transcriptomics
Abbreviations used : ECM, LCM, mRNA, UV
Plan
Supported by Procter & Gamble. |
|
Disclosure: Dr Kimball is a consultant for Procter & Gamble; Dr Tamura, Ms Mullins, Ms Soh, Dr Binder, Ms Annunziata, Dr Bascom, Dr Isfort, Mr Jarrold, Dr Kainkaryam, Dr Rocchetta, Dr Swift, Dr Tiesman, Ms Toyama, Dr Xu, Dr Yan, and Dr Osborne are employees of Procter & Gamble; and Drs Conley and Tung are employees of 23andMe. Dr Alora-Palli and Mr Houston have no conflicts of interest to declare. |
Vol 78 - N° 1
P. 29 - janvier 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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