Risk factors for positive or equivocal margins after wide local excision of 1345 cutaneous melanomas - 14/12/17
Abstract |
Background |
Positive or equivocal margins after wide local excision (WLE) complicate surgical management of cutaneous melanoma.
Objective |
To identify the frequency of and risk factors for positive or equivocal margins after WLE of cutaneous melanoma.
Methods |
Retrospective, single-center, cross-sectional study of 1345 consecutive melanomas treated with WLE.
Results |
The overall frequency of positive or equivocal margins was 4.2% (56/1345), ranging from 2.2% to 22.6%, depending on the size of the surgical margins, patient characteristics, biopsy history, and the clinicopathology of the melanoma. In descending order, independent risk factors associated with the greatest odds for positive or equivocal margins after multivariate analysis were noncompliance with recommended surgical margins (odds ratio [OR] 5.57, P = .002); anatomic location on the head, neck, hands, feet, genitals, or pretibial leg (OR 5.07, P < .001); histologic regression (OR 2.78, P = .007); in situ melanoma (OR 2.27, P = .011); multiple biopsies at the tumor site before WLE (OR 1.92 [per biopsy], P = .004); and increasing age (OR 1.049 [per year], P < .001).
Limitations |
This was a single-site, retrospective observational study.
Conclusions |
Clinicopathologic factors, especially location in cosmetically or functionally sensitive areas and noncompliance with recommended surgical margins, identified melanomas at increased risk for positive or equivocal margins after WLE.
Le texte complet de cet article est disponible en PDF.Key words : counseling, delayed reconstruction, equivocal margins, immediate reconstruction, incomplete excision, local recurrence melanoma, positive margins, wide local excision
Abbreviations used : AUC, CI, LM, OR, WLE
Plan
Funding sources: Drs Etzkorn and Sobanko are supported by Dermatology Foundation Clinical Career Development Awards in Dermatologic Surgery. |
|
Conflicts of interest: None declared. |
|
Reprints not available from the authors. |
Vol 77 - N° 2
P. 333 - août 2017 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?