Frequency of and risk factors for tumor upstaging after wide local excision of primary cutaneous melanoma - 14/12/17
Abstract |
Background |
Detecting a more advanced stage of the primary melanoma after wide local excision and reconstruction can complicate patient counseling about prognosis, management of surgical margins, and indications for sentinel lymph node biopsy.
Objective |
To identify the frequency of and risk factors associated with upstaging after wide local excision of primary melanoma.
Methods |
Retrospective, single center, cross-sectional study of 1332 consecutive in situ to stage T4a melanomas treated with wide local excision.
Results |
The overall rate of upstaging of melanoma was 3.9% (52/1332). After multivariate analysis, the greatest risk factor for upstaging was anatomic location on the head, neck, hands, feet, genitals, or pretibial leg (odds ratio [OR] 7.06, P < .001) followed by extension of the melanoma to the base of the biopsy specimen (OR 3.42, P < .001); the need for multiple preoperative scouting biopsies (OR 1.89, P = .004); older age (OR 1.03 per year, P = .002); and nonlentigo maligna histologic subtype (OR 3.6, P = .002).
Limitations |
This was a single-site, retrospective observational study.
Conclusions |
Clinicopathologic characteristics, particularly anatomic location on the head, neck, hands, feet, genitals, or pretibial leg and subtotal diagnostic biopsies, identify melanomas with an increased risk for upstaging.
Le texte complet de cet article est disponible en PDF.Key words : conventional excision, guidelines, melanoma, Mohs surgery, prognosis, reconstruction, sentinel lymph node biopsy, upstaging, wide local excision
Abbreviations used : AJCC, AUC, CI, LM, OR, SLNB
Plan
Funding sources: Drs Etzkorn and Sobanko are supported by a Dermatology Foundation Clinical Career Development Award in Dermatologic Surgery. |
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Conflicts of interest: None declared. |
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Reprints not available from the authors. |
Vol 77 - N° 2
P. 341-348 - août 2017 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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