Laparoscopic sterilization techniques are becoming accepted in veterinary medicine, and there has been interest in reducing the number and size of portals. Computer-controlled bipolar electrocoagulation devices facilitate sealing and dividing ovarian pedicles, reducing operative time. The 2-portal laparoscopic ovariectomy has been proved to be safe, feasible, and effective in dogs and cats, but has not yet been described in exotic companion mammals. Based on the author’s experience, the 2-portal laparoscopic ovariectomy seems to be safe and feasible in rabbits, but complications such as emergency conversion to laparotomy and severe postoperative ileus have occurred in pigs.