Treatment of vitiligo with the topical Janus kinase inhibitor ruxolitinib - 14/12/17
Abstract |
Background |
Existing therapies for vitiligo are limited in efficacy and can be associated with undesirable side effects. Topical Janus kinase inhibitors may offer a new therapeutic option for vitiligo.
Objective |
We sought to assess the role of topical ruxolitinib 1.5% cream, a Janus kinase inhibitor, in vitiligo treatment.
Methods |
This 20-week, open-label, proof-of-concept trial of twice-daily topical ruxolitinib 1.5% cream was conducted in 12 patients with a minimum of 1% affected body surface area of vitiligo. The primary outcome was percent improvement in Vitiligo Area Scoring Index from baseline to week 20.
Results |
Of 12 patients screened, 11 were enrolled and 9 completed the study (54.5% men; mean age, 52 years). Four patients with significant facial involvement at baseline had a 76% improvement in facial Vitiligo Area Scoring Index scores at week 20 (95% confidence interval, 53-99%; P = .001). A 23% improvement in overall Vitiligo Area Scoring Index scores was observed in all enrolled patients at week 20 (95% confidence interval, 4-43%; P = .02). Three of 8 patients responded on body surfaces and 1 of 8 patients responded on acral surfaces. Adverse events were minor, including erythema, hyperpigmentation, and transient acne.
Limitations |
Limitations of the study include the small sample size and open-label study design.
Conclusions |
Topical ruxolitinib 1.5% cream provided significant repigmentation in facial vitiligo and may offer a valuable new treatment for vitiligo.
Le texte complet de cet article est disponible en PDF.Key words : facial vitiligo, Janus kinase inhibitor, ruxolitinib, topical application, VASI, vitiligo
Abbreviations used : BSA, IFN, JAK, VASI
Plan
| Brooke Rothstein and Deep Joshipura contributed equally to this work. |
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| This study was supported in part by an Alpha Omega Alpha Carolyn L. Kuckein Student Research Fellowship and Incyte Corporation. Incyte Corporation was involved in review of the manuscript and provided the supply of study drug. Incyte Corporation was not involved in the collection, management, analysis, preparation, approval of the manuscript, or decision to submit the manuscript for publication. Alpha Omega Alpha Carolyn L. Kuckein Student Research Fellowship was not involved in the design or conduct of the study collection, management, analysis, preparation, review, or approval of the manuscript or decision to submit the manuscript for publication. |
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| Conflict of interest: None declared. |
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| Reprints not available from the authors. |
Vol 76 - N° 6
P. 1054 - juin 2017 Retour au numéro
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