The role of immunosuppression in squamous cell carcinomas arising in seborrheic keratosis - 14/12/17
, Karl Napekoski, MD c, Heidi Schuetz, BA a, Melissa Piliang, MD a, Wilma Bergfeld, MD a, Natasha Atanaskova Mesinkovska, MD, PhD a, dAbstract |
Background |
Seborrheic keratoses (SK) are common skin neoplasms considered to be benign. Reports of associated squamous cell carcinoma arising within seborrheic keratosis (SCC-SK) have been described.
Objective |
To describe the histopathologic characteristics of SCC-SK and identify predisposing factors in formation of these rare lesions.
Methods |
There were 162 cases of SCC-SK in a span of a decade (2003-2014). All of the histopathologic specimens and medical records were reviewed. Data from these patients were compared to a control group with seborrheic keratosis who were matched by age, sex, and location of lesion from the same time period (n = 162).
Results |
SCC-SK has the classic histopathologic features of SK, such as hyperkeratosis, parakeratosis, papillomatosis, and pseudohorn cysts. The areas of squamous cell carcinoma were characterized by areas of squamous dysplasia (100%), hypogranulosis (79.6%), squamous eddies (79.6%), solar elastosis (80.9%), and brown pigmentation (59.9%).
Patients with a history of immunosuppression had an increased risk for developing SCC-SK (19% vs 3%; P < .01), particularly when inhibition was transplant-associated (10% vs 0%; P < .01).
Limitations |
This was a single center, retrospective study.
Conclusion |
SCC-SK occurs more often in elderly men with a history of immunosuppression associated with organ transplants.
Le texte complet de cet article est disponible en PDF.Key words : elderly men, immunosuppression, malignant transformation, SCC-SK, seborrheic keratosis, squamous cell carcinomas, transplant
Abbreviations used : CI, OR, SCC-SK, SK
Plan
| Funding sources: None. |
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| Conflicts of interest: None declared. |
Vol 76 - N° 6
P. 1146-1150 - juin 2017 Retour au numéro
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