The epidemiology of pediatric melanoma is distinct from that seen in adults. This is more distinguishable when pediatric patients are separated into prepubertal and adolescent groups.
In this study, we compared epidemiologic, clinical, histologic, and molecular characteristics of pediatric superficial spreading melanoma (SSM) in prepubertal and adolescent patients to that in adults.
We reviewed our database for pediatric melanomas, comparing SSM data between pediatric and adult cases for pathologic stage at presentation, ratio of radial to vertical growth phase, average Breslow depth and mitotic index, and frequency of fluorescence in situ hybridization (FISH) positivity.
Of 84 pediatric melanomas, 38 were SSM, and 5 of the latter (6%) were prepubertal. There were no significant differences when pediatric and adult SSM were compared for stage at presentation, ratio of radial to vertical growth phase, average Breslow depth and mitotic count, or frequency of FISH positivity. A significant difference was detected for SSM arising from a precursor nevus (80% of pediatric cases versus 30% of adult cases).
Follow-up time was limited for both cohorts.
SSM melanoma is infrequent in childhood, particularly in the prepubertal years. Features such as tumor stage, Breslow depth, mitotic activity, and FISH positivity suggest morphologic and molecular characteristics similar to those of adult SSM.Le texte complet de cet article est disponible en PDF.
Key words : adolescent, children, FISH, radial growth phase, superficial spreading melanoma, vertical growth phase
Abbreviations used : FISH, SSM
| Supported by the IDP Foundation.
| Dr Gerami has served as a consultant for Myriad Genomics, DermTech Int, and Castle Biosciences and has received honoraria for this service. Drs Verzì, Wagner, Kruse, West, Wayne, and Guitart; Mr Bubley; Ms Haugh; and Mr Zhang have no conflicts of interest to declare. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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