Degree of ketonaemia and its association with insulin resistance after dapagliflozin treatment in type 2 diabetes - 01/02/18
Abstract |
Background |
Euglycaemic ketoacidosis has been reported after sodium–glucose cotransporter 2 (SGLT2) inhibitor treatment. However, the degree of ketonaemia and its metabolic effects have not been well investigated. Our study examined the degree of ketonaemia induced by SGLT2 inhibition and its association with metabolic profiles in type 2 diabetes mellitus (T2DM).
Methods |
Biochemical parameters, including insulin, glucagon, free fatty acid (FFA), β-hydroxybutyrate (BHB) and acetoacetate (ACA) levels, were measured in 119 T2DM patients after dapagliflozin treatment for>3 months, and compared with a matched control group.
Results |
Levels of total ketones, BHB and ACA were significantly higher in the dapagliflozin group than in the control group: 283.7±311.0 vs 119.8±143.8μmol/L; 188.3±226.6 vs 78.0±106.7μmol/L; and 94.1±91.3 vs 41.8±39.1μmol/L, respectively (all P<0.001). After dapagliflozin treatment, BHB was higher than the upper limit of normal (>440μmol/L) in 13 (10.9%) patients who had no relevant symptoms. BHB level after dapagliflozin treatment correlated positively with HbA1c (r=0.280), FFA levels (r=0.596) and QUICKI (r=0.238), and negatively with BMI (r=−0.222), insulin-to-glucagon ratio (r=−0.199) and HOMA-IR (r=−0.205; all P<0.05). On multivariable linear regression analysis, QUICKI was independently associated with BHB level.
Conclusion |
Ketone levels were higher in T2DM patients treated with dapagliflozin than in controls, but with no clinical symptoms or signs of ketonaemia. Low-grade ketonaemia after dapagliflozin treatment may also be associated with improved insulin sensitivity.
Le texte complet de cet article est disponible en PDF.Keywords : Acetoacetate, β-hydroxybutyrate, Free fatty acid, Insulin sensitivity, Ketone body, SGLT2 inhibitor
Abbreviations : ACA, Adipo-IR, BMI, eGFR, FFA, HOMA, IR, SD, SGLT2, SNUBH, QUICKI
Plan
☆ | Data from this study were presented in part at the American Diabetes Association 2017 Scientific Sessions, San Diego, California, 9–12 June 2017. |
Vol 44 - N° 1
P. 73-76 - février 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.