Thymoquinone reduces mortality and suppresses early acute inflammatory markers of sepsis in a mouse model - 04/02/18
pages | 5 |
Iconographies | 3 |
Vidéos | 0 |
Autres | 0 |
Abstract |
Background |
Sepsis is a severe systemic condition caused by an excessive inflammatory response to microbial infections, which often results in high mortality.
Aims |
In the present study, the therapeutic effects of thymoquinone were investigated for Gram-negative bacteria-induced sepsis in mice.
Methods |
Thymoquinone was administered as 1or 2 mg/kg intraperitoneally 2 h after Escherichia coli (E. coli) challenge. Animal morality was assessed up to 96 h post infection and inflammatory proteins levels were measured 6 h after thymoquinone treatment in various groups using enzyme-linked immunosorbent assay (ELISA) techniques.
Key findings |
The E. coli inoculation markedly increased the level of plasma cytokines, including tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-2, IL-6 and IL-10. In addition, the levels of selected early sepsis biomarkers such as CRP, VEGF and ESM-1 were amplified in the septic group. Treatment with thymoquinone significantly downregulated the circulating concentrations of the inflammatory proteins (p < 0.05). In addition, ∼75% of mice in the thymoquinone (1 mg/kg) group survived at 96h of observation compared with ∼8% of the untreated group (p = 0.0016).
Significance |
The present results indicate that thymoquinone suppresses acute inflammatory responses induced by sepsis including early stage biomarkers and reduces sepsis-related mortality. These findings suggest that thymoquinone could be of a potential therapeutic value in the management of sepsis.
Le texte complet de cet article est disponible en PDF.Keywords : Thymoquinone, E. coli, Sepsis, Inflammation, Cytokines, Biomarkers, Mortality
Plan
Vol 98
P. 801-805 - février 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?