Long non-coding RNA XLOC_008466 acts as an oncogenic molecular in cervical cancer tumorigenesis - 04/02/18

Doi : 10.1016/j.biopha.2017.11.143

Fang Guo ^a,^⁎ , Yun-Zhi Chen ^b, Liu Li ^a, Cong Chen ^a, Jian-Hua Jin ^a, Jie Yang ^a, Jing-Jing Chen ^a, Xin-Yan Chen ^a, Min Guo ^a, Yu-Mei Chen ^a
^a Department of Gynaecology and Obstetrics, the Third Clinical College of Wenzhou Medical University, Wenzhou People's Hospital, Wenzhou, Zhejiang, 325000, China
^b Department of General Surgery, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China

^⁎Corresponding author at: Department of Gynaecology and Obstetrics, the Third Clinical College of Wenzhou Medical University, Wenzhou People's Hospital, Canghou Street, No. 57, Wenzhou, Zhejiang, 325000, China.Department of Gynaecology and Obstetricsthe Third Clinical College of Wenzhou Medical UniversityWenzhou People's HospitalWenzhouZhejiang325000China

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Abstract

Cervical cancer is one of the most common malignant carcinomas in the female reproductive system. Long non-coding RNAs (lncRNAs) have been verified to participate in the tumorigenesis of cervical cancer. In present study, we investigate the role of lncRNA XLOC_008466 in the occurrence and progression of cervical cancer. Results showed that XLOC_008466 expression was up-regulated in cervical cancer tissue and cells compared to normal controls. In vitro functional experiments, CCK-8 assay and colony formation assay showed that XLOC_008466 knockdown suppressed the proliferation of cervical cancer cells. Flow cytometry and transwell assay showed that XLOC_008466 knockdown induced G0/G1 phase arrest and aggravated the apoptosis. In vivo, XLOC_008466 knockdown inhibited the tumor growth. Bioinformatics analysis revealed that XLOC_008466 sponged miR-216b with the complementary binding sites at 3’-UTR. Overall, our study reveals the tumor promoting role of XLOC_008466 in cervical cancer carcinogenesis, providing a novel molecular mechanism and therapeutic target for cervical cancer.

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Keywords : Cervical cancer, XLOC_008466, Long non-coding RNA, miR-216b

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Vol 98

P. 88-94 - février 2018 Retour au numéro

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Long non-coding RNA XLOC_008466 acts as an oncogenic molecular in cervical cancer tumorigenesis - 04/02/18

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