T-cell inhibitors for atopic dermatitis - 21/02/18
Abstract |
The management of atopic dermatitis is changing with the development of novel biologic agents to target specific molecules in the inflammatory cascade. Following the ability of dupilumab has proved its ability to act on the interleukin 4 receptor in treating atopic dermatitis. Thymic stromal lymphopoietin monoclonal antibody (AMG157/MEDI9929) and OX40 blocking antibody (GBR 830) were developed by targeting the same pathway as dupilumab further upstream. The clinical data on the efficacy for these drugs are not yet known. There is some early evidence that AMG157/MEDI9929 attenuates most measures of allergen-induced asthmatic responses. However, there are no public data on its ability to treat atopic dermatitis. In a phase 2a study, GBR 830 showed at least a 50% reduction in the Eczema Area and Severity Index scores of 17 of 23 patients, but it was not sufficiently powered for identification of statistical differences between GBR 830 versus placebo. Although there is potential for these 2 drugs to greatly improve the management of severe atopic dermatitis, significant clinical trials have not yet been completed to prove efficacy, and there are not yet any available phase 3 clinical trials, which are needed to truly evaluate their efficacy in affecting T-cells.
Le texte complet de cet article est disponible en PDF.Key words : atopic dermatitis, immunomodulators, OX40, T cells, tezepelumab, thymic stromal lymphopoietin
Abbreviations used : AD, IL, Th2, TSLP
Plan
Publication of this article was supported by Leo Pharma, Bayer, and Sanofi/Regeneron. |
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Funding sources: Supported by Bayer, LEO Pharma, and Sanofi. |
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Conflicts of interest: None disclosed. |
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Reprints not available from the authors. |
Vol 78 - N° 3S1
P. S67-S70 - mars 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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