Merkel cell carcinoma: An update and review : Pathogenesis, diagnosis, and staging - 28/02/18
Abstract |
Merkel cell carcinoma (MCC) is an uncommon primary cutaneous neuroendocrine cancer. It most commonly presents as an indurated plaque or nodule on sun-damaged skin in elderly patients and is characterized by high rates of local recurrence and nodal metastasis. Survival at 5 years is 51% for local disease and as low as 14% for distant disease, which underscores the aggressive nature of this tumor and challenges in management. Advances in immunology and molecular genetics have broadened our understanding of the pathophysiology of MCC and expanded our therapeutic arsenal. With this comprehensive review, we provide an update of MCC epidemiology, pathogenesis, clinical presentation, diagnostic evaluation and prognostic markers. The second article in this continuing medical education series explores the evolving landscape in MCC management.
Le texte complet de cet article est disponible en PDF.Key words : cytokeratin-20, Merkel cell carcinoma, Merkel cell polyomavirus, Merkel cells
Abbreviations used : CK-20, LT, MC, MCC, MCV, NCCN, PET/CT, SLNB, ST, UV
Plan
Funding sources: None. |
|
Conflicts of interest: None disclosed. |
|
Date of release: March 2018 |
|
Expiration date: March 2021 |
Vol 78 - N° 3
P. 433-442 - mars 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?