Clinicopathologic features of 28 cases of nail matrix nevi (NMNs) in Asians: Comparison between children and adults - 28/02/18
Abstract |
Background |
Clinical distinction between nail matrix nevus (NMN) and subungual melanoma (SUM) can be challenging. More precise delineation of the clinicodermoscopic characteristics specific for NMNs is needed.
Objective |
We sought to analyze the clinicopathologic features of childhood and adult NMNs and to propose clinicodermoscopic features that can aid in differentiating NMNs from SUM.
Methods |
We retrospectively reviewed clinical, dermoscopic, and histologic findings of patients (20 children and 8 adults) in whom NMN was diagnosed between 2012 and 2015.
Results |
Except for 2 cases of total melanonychia, the affected nails demonstrated longitudinal melanonychia sharply demarcated from the adjacent nail plate. Melanonychia was wider among children than among adults (P = .002). Nail dystrophy was more frequent in wider lesions (P = .028). Hutchinson's sign was observed in pediatric cases at the hyponychium and/or proximal nailfold cuticles. All hyponychial pigmentations demonstrated a longitudinal brush pigmentation pattern under dermoscopy.
Limitations |
This was a retrospective study of Asians in a single center.
Conclusion |
Our study is the largest case series to date of biopsy-confirmed NMNs. It highlighted important clinicodermoscopic differences between pediatric and adult NMNs. We propose that in pediatric cases of longitudinal melanonychia presenting as a sharply demarcated pigment band of even width, the presence of Hutchinson's sign with longitudinal brush pigmentation may favor a diagnosis of NMN over SUM.
Le texte complet de cet article est disponible en PDF.Key words : Hutchinson's sign, melanonychia, nail biopsy, nail dystrophy, nail matrix nevus, retrospective study
Abbreviations used : NMN, SUM, ndNEC, LBP
Plan
Funding sources: None. |
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Conflicts of interest: None disclosed. |
Vol 78 - N° 3
P. 479-489 - mars 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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