Evaluation of effect of letrozole prior to misoprostol in comparison with misoprostol alone in success rate of induced abortion - 07/03/18
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 5 |
| Iconographies | 0 |
| Vidéos | 0 |
| Autres | 0 |
Abstract |
Background |
Abortion, spontaneous or induced, is a common complication of pregnancy and exploration of available and safe regimens for medical abortion in developing countries seems crucial.
Aims |
The present study was aimed to assess the effect of letrozole in combination with misoprostol in women eligible for legal therapeutic abortion with gestational age ≤14weeks.
Materials and methods |
This clinical randomized trial was conducted on 78 women who were candidate of medical abortion and eligible for legal abortion with gestational age ≤14 weeks that were randomly divided into two groups of case and controls. Case group received daily oral dose of 10mg letrozole for three days followed by vaginal misoprostol. In control group the patients received only vaginal misoprostol. The rate of complete abortion, induction-of-abortion time, and side-effects were assessed.
Results |
Complete abortion was observed in 30 patients (76.9%) in case group and 9 (23.1%) cases were failed. In control group there was 16 (41.03%) complete abortions and 23 (58.97%) cases were failed to abort. Patients with gestational age of between 6 and 10 weeks did not show significant difference in both groups (P=0.134). Regarding pregnancy remnants there were significant differences between two groups (P=0.034). The time form admission to discharge in case groups were significantly shorter than those in control group (P=0.001). The indication for curettage in case group was significantly less than control group (P=0.001).
Conclusion |
A 3-day course of letrozole (10mg/daily) followed by misoprostol was associated with a higher complete abortion and lower curettage rates and reduction in time from admission to discharge in women with gestational age ≤14 weeks compared to misoprostol alone.
Le texte complet de cet article est disponible en PDF.Keywords : Letrozole, Misoprostol, Abortion
Plan
Vol 47 - N° 3
P. 113-117 - mars 2018 Retour au numéro
Article précédent
- Are there risk factors for false-positive malformation diagnoses on obstetric ultrasound? A nested case-control study
- A. Debost-Legrand, I. Perthus, O. Rivière, D. Gallot, D. Lémery, F. Vendittelli
- Factors affecting rotation of occiput posterior position during the first stage of labor
- P. Blanc-Petitjean, C. Le Ray, F. Lepleux, A. De La Calle, M. Dreyfus, A.A. Chantry
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?