All-cause mortality in patients with basal and squamous cell carcinoma: A systematic review and meta-analysis - 14/03/18
Abstract |
Background |
There are varying reports of the association of basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (SCC) with mortality.
Objective |
To synthesize the available information on all-cause mortality after a diagnosis of BCC or SCC in the general population.
Methods |
We searched PubMed (1966-present), Web of Science (1898-present), and Embase (1947-present) and hand-searched to identify additional records. All English articles that reported all-cause mortality in patients with BCC or SCC were eligible. We excluded case reports, case series, and studies in subpopulations of patients. Random effects model meta-analyses were performed separately for BCC and SCC.
Results |
The searches yielded 6538 articles, and 156 were assessed in a full-text review. Twelve studies met the inclusion criteria, and 4 were included in the meta-analysis (encompassing 464,230 patients with BCC and with 175,849 SCC), yielding summary relative mortalities of 0.92 (95% confidence interval, 0.83-1.02) in BCC and 1.25 (95% confidence interval, 1.17-1.32) in SCC.
Limitations |
Only a minority of studies controlled for comorbidities. There was significant heterogeneity in meta-analysis (χ2 P < .001, I2 > 98%), but studies of SCC were qualitatively concordant: all showed statistically significant increased relative mortality.
Conclusions |
We found that patients with SCC are at higher risk for death from any cause compared with the general population.
Le texte complet de cet article est disponible en PDF.Key words : all-cause mortality, basal cell carcinoma, cutaneous squamous cell carcinoma, keratinocyte carcinoma, meta-analysis, systematic review
Abbreviations used : BCC, CI, DCR, GFC, SCC, SMR
Plan
| Drs Wehner and Cidre Serrano contributed equally to this article. |
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| Supported by the National Institutes of Health through the National Center for Research Resources (grant KL2RR024130 to EL), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (grants K24 AR052667 and R01 AR 054983 to MMC), and the Claude D. Pepper Older Americans Independence Center at the National Institute on Aging, National Institutes of Health (grant P30 AG044281 to EL), as well as by Harvard Medical School's Scholars in Medicine Office (WCS). No funding sources were involved in the study design; data collection, management, analysis, and interpretation; manuscript preparation, review and approval; or the decision to submit the manuscript for publication. Dr Linos was supported by the Dermatology Foundation through a Health Care Policy Career Development Award. |
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| Conflicts of interest: None disclosed. |
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| Dr Linos had full access to all of the data in the study and takes responsibility for the integrity of the data, the accuracy of the data analysis, and study supervision. Drs Wehner, Cidre Serrano, Chren, and Linos take responsibility for the study concept and design, as well as for administrative, technical, or material support. Drs Wehner, Cidre Serrano, Nosrati, Schoen, Boscardin, and Linos take responsibility for acquisition, analysis, and interpretation of data. Drs Wehner, Cidre Serrano, and Linos take responsibility for drafting of the manuscript. Drs Wehner, Cidre Serrano, Nosrati, Boscardin, Chren, and Linos take responsibility for critical revision of the manuscript for important intellectual content. |
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| Supplemental Table I available at www.jaad.org. |
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| Reprints not available from the authors. |
Vol 78 - N° 4
P. 663 - avril 2018 Retour au numéro
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