Comorbidity scores associated with limited life expectancy in the very elderly with nonmelanoma skin cancer - 12/05/18
Abstract |
Background |
There is controversy regarding treatment of nonmelanoma skin cancer (NMSC) in very elderly individuals, with some suggesting that this population may not live long enough to benefit from invasive treatments. Tools to assess limited life expectancy (LLE) exist, but performance in the population of very elderly individuals with NMSC has not been well defined.
Objective |
Define comorbidity scores associated with LLE in very elderly individuals presenting for management of NMSC.
Methods |
A retrospective review of 488 patients age 85 or older presenting for NMSC management between July 1999 through December 2014 was performed. Comorbidities were scored by using the Adult Comorbidity Evaluation-27 (ACE-27) and age-adjusted Charlson comorbidity index (ACCI). Dates of death, follow-up, and overall survival were determined.
Results |
ACE-27 and ACCI scores were associated with overall survival; at scores of 3 and 7+, respectively, both were associated with less than 50% survival at 4 years. Patients who underwent Mohs micrographic surgery survived a median of 20 months longer than patients who did not.
Limitations |
Retrospective study design and referral bias.
Conclusions |
ACE-27 and ACCI scores predicted LLE. The cohort presenting for Mohs micrographic surgery had improved survival, despite similar intercohort comorbidity. This suggests that additional factors contributed to survival and that age and comorbidities alone are inadequate for making NMSC treatment decisions in very elderly individuals.
Le texte complet de cet article est disponible en PDF.Key words : comorbidity, elderly, limited life expectancy, NMSC, Mohs micrographic surgery, skin cancer
Abbreviations used : ACCI, ACE-27, LLE, MMS, NMSC
Plan
| Funding sources: Supported by the National Cancer Institute of the National Institutes of Health (NIH) under award No. R25CA020449 and in part through the National Institutes of Health/National Cancer Institute Cancer Center Support Grant P30 CA008748. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. |
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| Conflicts of interest: None disclosed. |
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| The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. |
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| Reprints not available from the authors. |
Vol 78 - N° 6
P. 1119-1124 - juin 2018 Retour au numéro
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