Clinical and histologic features of Mycoplasma pneumoniae–related erythema multiforme: A single-center series of 33 cases compared with 100 cases induced by other causes - 18/06/18
Abstract |
Background |
Mycoplasma pneumoniae infection has been documented in erythema multiforme (EM) and Stevens-Johnson syndrome–toxic epidermal necrosis (SJS-TEN). Clinical aspects of M pneumoniae–related EM have been poorly described in the literature.
Objective |
To highlight differences between M pneumoniae EM and non–M pneumoniae EM.
Methods |
This single-center, retrospective cohort study included all patients admitted to our dermatology department for EM during 2000-2015. We compared epidemiologic, clinical, and histologic data and follow-up for M pneumoniae EM and non–M pneumoniae EM cases.
Results |
Thirty-three patients with M pneumoniae EM were compared with 100 patients with non–M pneumoniae EM. Disease onset in winter was more frequent with M pneumoniae EM (P = .003). Acrally distributed lesions (32% vs 88%, P < .0001) and typical targets (45% vs 74%, P = .01) were less common in M pneumoniae EM than non–M pneumoniae EM. Multiple (≥2) mucousal membrane involvement was more frequent in M pneumoniae EM than non–M pneumoniae EM (97% vs 60%; P < .0001), as were mucosal and respiratory tract sequelae (P < .05). The mean hospital stay was longer with M pneumoniae EM patients: 9.5 days versus 5.1 days (P = .0002). A TEN-like pattern was observed in all 14 (100%) M pneumoniae EM skin biopsies versus 10 of 27 (48%) non–M pneumoniae EM biopsies (P < .001).
Limitations |
The retrospective design.
Conclusion |
M pneumoniae EM has a distinctive presentation compared with non–M pneumoniae EM, with more diffuse and atypical targets, more mucositis and respiratory tract sequelae. Histologic data show a TEN-like pattern in all M pneumoniae EM skin samples.
Le texte complet de cet article est disponible en PDF.Key words : atypical targets, clinical, erythema multiforme, histological, Mycoplasma pneumoniae, mucositis, presentation, sequelae
Abbreviations used : EM, HSV, MIRM, SJS, SJS-TEN, TEN
Plan
Drs Amode, Ingen-Housz-Oro, Wolkenstein, and Chosidow contributed to this work equally. |
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Funding sources: None. |
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Conflicts of interest: None disclosed. |
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Reprints not available from the authors. |
Vol 79 - N° 1
P. 110-117 - juillet 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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