Demographics and outcomes of stage I and II Merkel cell carcinoma treated with Mohs micrographic surgery compared with wide local excision in the National Cancer Database - 18/06/18
Abstract |
Background |
The optimal surgical approach (wide local excision [WLE] vs Mohs micrographic surgery [MMS]) for treating Merkel cell carcinoma (MCC) is yet to be determined.
Objective |
To compare survival outcomes in patients with early-stage MCC treated with MMS versus with WLE.
Methods |
A retrospective review of all cases in the National Cancer Database (NCDB) of MCC of clinical stage I or II MCC treated with WLE or MMS was performed.
Results |
A total of 1795 cases of stage I or II MCC who underwent WLE (n = 1685) or MMS (n = 110) were identified. There was no difference in residual tumor on surgical margins between the 2 treatment groups (P = .588). On multivariate analysis, there was no difference in overall survival between the treatment modalities (adjusted hazard ratio, 1.02; 95% confidence interval, 0.72-1.45; P = .897). There was no difference in overall survival between the 2 groups on propensity score–matched analysis.
Limitations |
Disease-specific survival was not reported, as these data are not available in the National Cancer Database.
Conclusions |
MMS appears to be as effective as WLE in treating early-stage MCC.
Le texte complet de cet article est disponible en PDF.Key words : adjuvant radiation, cutaneous oncology, locoregional control, Merkel cell carcinoma, Mohs micrographic surgery, National Cancer Data Base, survival, wide local excision
Abbreviations used : AJCC, CI, CRT, HR, MCC, MMS, NCDB, NOS, OS, RT, WLE
Plan
Drs Truong and Sahni are colast authors. |
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Funding sources: None. |
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Conflicts of interest: None disclosed. |
Vol 79 - N° 1
P. 126 - juillet 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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