Relationship between metabolic syndrome and knee osteoarthritis - 15/07/18
Résumé |
Introduction/Background |
Recent studies suggest that metabolic disorders that provoke systemic inflammation are associated with knee OA. However, most studies have only examined associations between single metabolic diseases and knee OA. This study investigated the effect of metabolic syndrome (MS) on development of knee OA.
Material and method |
Data were obtained from the 2010 to 2012 Korea National Health and Nutrition Examination Survey. Subjects with knee OA (≥ Kellgren–Lawrence grade 2) and severe knee OA (≥ Kellgren–Lawrence grade 3) were evaluated based on radiologic findings. Medical information, in accordance with MS, and demographic data were obtained from survey records. Multivariate regression analysis was performed to investigate the relationship between knee OA and MS, in addition to various demographic factors. Analyses were adjusted by age group (model 1), or by age group, education, smoking, alcohol consumption, and physical activity (model 2).
Results |
In women, MS increased the risk of knee OA (odds ratio [OR]=1.644, P-value<0.001 and OR=1.608, P-value<0.001, respectively, for model 1 and 2) and severe knee OA (OR=1.593, P-value<0.001 and OR=1.559, P-value<0.001, respectively, for model 1 and 2). However, in men, knee OA and severe knee OA were not associated with MS. As the number of MS components increased, knee OA and severe knee OA generally increased in women. However, this trend was not definite in men.
Conclusion |
MS affects the development of knee OA and severe knee OA in women. Additionally, dose-response relationships were observed between MS components and knee OA. However, these relationships were not definite in men.
Le texte complet de cet article est disponible en PDF.Keywords : Metabolic syndrome, Osteoarthritis
Plan
Vol 61 - N° S
P. e129 - juillet 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.