New classification of tauopathies - 09/08/18
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Abstract |
Tauopathies are a group of neurodegenerative diseases characterized by pathological intracellular deposits of the protein tau. Isoform composition, morphology and anatomical distribution of cellular tau-immunoreactivities are defining distinct tauopathies as molecular pathological disease entities. The clinical spectrum of tauopathies includes syndromes with primary motor symptoms and with primary cognitive dysfunction. The traditional syndrome-based classification is currently being complemented by a molecular-pathological classification. While the syndrome-based classification is helpful to select symptomatic therapies, and to generate clinical working hypotheses about underlying etiologies, the molecular-pathological classification is most important for the development and application of molecularly tailored disease-modifying therapies.
Le texte complet de cet article est disponible en PDF.Keywords : Tauopathies, Corticobasal degeneration, Corticobasal syndrome, Progressive supranuclear palsy, Richardson's syndrome
Abbreviations : AGD, ARTAG, bvFTD, CBD, CBS, CTE, FTD, FTLD, FTLD-MAPT, GGT, nfavPPA, NFT, PART, PGF, PiD, PPA, PSP, PSP-P, svPPA, FTDP-17
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