Childhood trauma but not FKBP5 gene variants associated with peritraumatic dissociation in female rape survivors - 31/08/18

Doi : 10.1016/j.ejtd.2018.02.002

E. Thomas ^a,^b,^⁎ , S.M.J. Hemmings ^a,^d,^c, G. Spies ^a,^c, J. Nothling ^b,^c, S. Seedat ^a,^b,^c
^a South African Research Chairs Initiative (SARChI), PTSD program, department of psychiatry, Stellenbosch university, South Africa
^b Department of psychiatry, faculty of medicine and health sciences, Stellenbosch university, P.O. Box 19063, Tygerberg, 7505 Stellenbosch, South Africa
^c MRC Unit on Anxiety and Stress Disorders, department of psychiatry, Stellenbosch university, South Africa
^d Division of molecular biology and human genetics, Stellenbosch university, South Africa

^⁎Corresponding author. Department of psychiatry, faculty of medicine and health sciences, Stellenbosch university, P.O. Box 19063, Tygerberg, 7505 Stellenbosch, South Africa.Department of psychiatry, faculty of medicine and health sciences, Stellenbosch university, P.O. Box 19063, Tygerberg, 7505 Stellenbosch, South Africa.

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Abstract

Introduction

Peritraumatic dissociation has been shown to be a strong predictor for development of PTSD.

Objective

This study explored the relationship of four putative FK506 binding protein 5 (FKBP5) genetic variants and childhood trauma in predicting peritraumatic dissociation.

Method

Extracted DNA from 81 female rape survivors in Cape Town, South Africa were analysed for common FKBP5 polymorphisms. Dissociative experiences, childhood trauma, depression and resilience were also measured.

Results

Childhood trauma was associated with a significant increase in peritraumatic dissociation, whilst resilience conferred a significant protective effect. No significant associations were observed between the single loci or haplotypes under investigation and peritraumatic dissociation.

Conclusion

This study provides evidence that, among female rape survivors, exposure to childhood trauma may increase risk of peritraumatic dissociation independent of genetic variation of the FKBP5 gene.

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Keywords : Childhood trauma, FKBP5 gene, Interpersonal violence dissociation, Post-traumatic stress disorder

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Vol 2 - N° 3

P. 125-129 - juillet 2018 Retour au numéro

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Childhood trauma but not FKBP5 gene variants associated with peritraumatic dissociation in female rape survivors - 31/08/18

Abstract

Introduction

Objective

Method

Results

Conclusion

Plan

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