Ethnic differences and comorbidities of 909 prurigo nodularis patients - 19/09/18
Abstract |
Background |
Prurigo nodularis (PN) is a poorly understood, understudied pruritic dermatosis that reduces quality of life.
Objective |
To characterize the demographics and comorbidities associated with PN.
Methods |
Cross-sectional study of patients 18 years and older who were seen at the Johns Hopkins Health System between December 6, 2012, and December 6, 2017.
Results |
Over the past 5 years, 909 patients with PN were seen at Johns Hopkins Health System. African American patients were 3.4 times more likely to have PN than white patients were (odds ratio [OR], 3.4; 95% confidence interval [CI], 2.9-3.9; P < .001). A comparison of the study patients and race-matched controls revealed that PN was significantly associated with a variety of systemic, cardiovascular, and psychiatric comorbidities, including chronic kidney disease, chronic hepatitis C, chronic obstructive pulmonary disease, congestive heart failure, depression, and atopic dermatitis. Black patients with PN were 10.5 times more likely (OR, 10.5; 95% CI, 7.9-13.9; P < .001) to have HIV than were race-matched controls with atopic dermatitis, and 8 times more likely (OR, 8.0; 95% CI, 5.7-11.1; P < .001) to have HIV than were African American patients with psoriasis.
Limitations |
Our data describe patients seen by 1 hospital system. Our data identify associated conditions and comorbidities but are unable to support a causal relationship.
Conclusion |
PN disproportionately affects African Americans and is associated with several systemic conditions, including HIV, chronic kidney disease, and diabetes.
Le texte complet de cet article est disponible en PDF.Key words : atopic dermatitis, chronic kidney disease, HIV, itch, PN, prurigo nodularis, pruritus, psoriasis
Abbreviations used : AD, COPD, JHHS, IL, PN
Plan
| Funding sources: Dr Kwatra received a grant from the Skin of Color Society. |
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| Disclosure: Dr Kwatra is an advisory board member for Menlo and Trevi Therapeutics. Dr Pereira has a grant from the European Academy of Dermatology and Venereology (EADV grant 2016-012). Dr Kang served on the advisory board for Menlo Therapeutics and received an honorarium for his service. Ms Boozalis, Ms Tang, Dr Patel, Dr Semenov, and Dr Stander have no conflicts of interest to disclose. |
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| The content in this manuscript has not been published or submitted for publication elsewhere. All the authors have contributed significantly and are in agreement with the content of the manuscript. |
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| Reprints not available from the authors. |
Vol 79 - N° 4
P. 714 - octobre 2018 Retour au numéro
Article précédent
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