Urine Xanthine Crystals in Tumor Lysis Syndrome - 19/09/18
Doi : 10.1016/j.urology.2018.07.009
Ayumi Omokawa a, ⁎ 
, Mariko Oguma b, Shigeharu Ueki a, Tomoo Saga a, Makoto Hirokawa a
, Mariko Oguma b, Shigeharu Ueki a, Tomoo Saga a, Makoto Hirokawa a a Department of General Internal Medicine and Clinical Laboratory Medicine, Akita University Graduate School of Medicine, Akita 010-8543, Japan
b Central Laboratory Division, Akita University Hospital, Akita 010-8543, Japan
⁎Address correspondence to: Ayumi Omokawa, MD, PhD, Department of General Internal Medicine and Clinical Laboratory Medicine, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita City, Akita 010-8543, Japan.Department of General Internal Medicine and Clinical Laboratory MedicineAkita University Graduate School of Medicine, 1-1-1 HondoAkita CityAkita010-8543Japan
Sous presse. Épreuves corrigées par l'auteur.
Disponible en ligne depuis le Wednesday 19 September 2018
Abstract |
Urine xanthine crystals are remarkably rare but can be observed by routine urine microscopy. We report the results of a 67-year-old man with T-cell-prolymphocytic leukemia whose urine contained xanthine crystals after chemotherapy and prophylactic administration of febuxostat. Accumulation of xanthine was due to tumor lysis syndrome causing a massive release of DNA. The metabolized DNA caused an increase of xanthine, which was not readily converted to uric acid by xanthine oxidase because of febuxostat inhibition of this enzyme.
Le texte complet de cet article est disponible en PDF.| Financial Disclosure: The authors declare that they have no relevant financial interests. |
© 2018
Elsevier Inc. Tous droits réservés.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?