Reduced brain volumes in children of women with epilepsy: A neuropsychological and voxel based morphometric analysis in pre-adolescent children - 02/10/18
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| Iconographies | 2 |
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Highlights |
• | Mean FSIQ was lower in children with antenatal AED exposure (CAED) compared to controls (P=0.001) |
• | CAED had also significantly reduced TBV,GMV (P<0.001) |
• | Mean CSF volume was significantly larger for the CAED group (P<0.001) |
Abstract |
Background and purpose |
Children of Women with Epilepsy with antenatal exposure to antiepileptic drugs (CAED) have reduced neuropsychological functions. We aimed to explore the anatomical basis for this impairment by comparing the brain volumes of CAED with that of matched healthy children without antenatal AED exposure (COAED).
Materials and methods |
CAED aged 8–12 years were recruited from the Kerala Registry of epilepsy and pregnancy that prospectively follows up children of women with epilepsy and COAED from children attending the imaging department for minor illnesses. Maternal clinical details and the neuropsychological data including IQ of CAED and COAED were obtained. Total intracranial volume (TBV), grey matter volume (GMV), white matter volume (WMV) and volumes of deep grey matter were measured by Voxel Based Morphometry.
Results |
We studied 30 CAED (mean age 10.8+1.11 years) and 35 COAED (mean age 10.64+1.26). The antenatal AED exposure for the CAED was monotherapy for 8 children and polytherapy for 22 children. The CAED had significantly lower (P<0.001) IQ (77.5+13.8), TBV(1259.55±169.85mL) and GMV (672.51±85.42 mL) compared to the IQ (87.0+13.5), TBV(1405.37±161mL) and GMV (745.427±86.69 mL) of COAED. CAED had lower volumes for Lt Inferior Triangular Gyrus, and hippocampi on both sides, when compared to COAED. Group analysis CAED showed less GMV (P<0.05) for left inferior and middle frontal gyri relative to COAED.
Conclusions |
These observations point towards an anatomical basis of lower GMV for the lower neuropsychological functions in children with antenatal AED exposure.
Le texte complet de cet article est disponible en PDF.Keywords : Voxel based morphometry, Children of woman with epilepsy, Antiepileptic drugs, Total intracranial volume, Grey matter volume, White matter volume
Plan
Vol 45 - N° 6
P. 380-385 - octobre 2018 Retour au numéro
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