Lichen planus and lichenoid dermatoses : Clinical overview and molecular basis - 15/10/18
Abstract |
Deriving from the Greek word λειχήν for “tree moss” and the Latin word planus for “planar,” lichen planus is a relatively uncommon and heterogeneous cutaneous disorder that typically develops in middle-aged adults. Despite the significant clinical burden associated with the disorder, little well-conducted molecular research has been undertaken, possibly because of heterogeneity impeding consistent and confident phenotyping. The multiple variants of lichenoid disease bear overlapping clinical and pathologic features despite manifesting as distinct clinical disorders. The first article in this 2-part continuing medical education series provides a comprehensive overview of the clinical and pathologic characteristics of cutaneous lichenoid dermatoses and links these manifestations to recent advances in our understanding of the underlying pathobiology of such diseases.
Le texte complet de cet article est disponible en PDF.Key words : lichen planus, lichenoid inflammation, lichenoid variants, molecular basis of lichenoid inflammation
Abbreviations used : LP, LPP, NLP, HCV, LDE, LPLK, LS, BP, LE, IL, IFN, HLA, SNP
Plan
Dr Tziotzios and Mr Lee contributed equally to this article. |
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Funding sources: None. |
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Conflicts of interest: None disclosed. |
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Date of release: November 2018 |
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Expiration date: November 2021 |
Vol 79 - N° 5
P. 789-804 - novembre 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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