Sinusoidal obstruction syndrome/veno-occlusive disease complication in lymphoma patients treated with oxaliplatin-based regimen: A case series report - 02/11/18
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Abstract |
Aim |
SOS/VOD is a relevant clinical syndrome that usually appears early after hematopoietic stem cell transplantation. The purpose of this article was to report a case series of SOS/VOD in non-susceptible patients and draw physicians’ attention to the plausible relationship between liver injury and oxaliplatin-based chemotherapy, preceding autologous transplantation.
Methods |
In this study, we report a case series of SOS/VOD in 4 lymphoma patients following autologous transplantation. The data were collected between July 2013 and November 2015 by analyzing patient's characteristics and outcomes.
Results |
We noticed 4 severe cases of SOS with unusual presentations in patients who did exhibit few classical risk factors. These patients received R-DHAO before transplantation.
Conclusions |
Physicians need to be aware that oxaliplatin-based regimen could contribute to SOS/VOD complications in hematological patients.
Le texte complet de cet article est disponible en PDF.Keywords : SOS/VOD complication, Autologous transplantation, Oxaliplatin-based regimen
Plan
Vol 66 - N° 4
P. 107-110 - novembre 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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