Second primary melanomas: Increased risk and decreased time to presentation in patients exposed to tanning beds - 10/11/18
Abstract |
Background |
Melanoma incidence has increased; the primary modifiable risk factor is ultraviolet radiation (UVR) from the sun or artificial UVR (arUVR) from tanning beds.
Objective |
To determine whether patients who developed melanoma after arUVR exposure from tanning beds have unique characteristics.
Methods |
A retrospective study of 434 melanoma patients was performed. Patients who consented at the initial appointment completed a questionnaire regarding phenotypic traits, medical history, and UVR exposure.
Results |
Compared with patients aged ≥40 years, younger patients, especially women, had greater lifetime exposure to arUVR. At any age, patients with multiple primary melanomas had a higher probability of exposure to arUVR. For all patients with additional primary melanomas, those exposed to arUVR acquired their second primary melanoma significantly earlier; 67% of patients exposed to arUVR through tanning beds had their second primary diagnosed at the time of or within 1 year of their original diagnosis compared with 28% of nontanners (P = .011). Median time to diagnosis of second primary melanoma in patients exposed to arUVR versus those not exposed was 225 days versus 3.5 years, respectively (P = .027).
Limitations |
The study was conducted in 1 geographic area with a relatively small sample size.
Conclusion |
Our findings provide evidence for heightened surveillance in melanoma patients exposed to arUVR.
Le texte complet de cet article est disponible en PDF.Key words : tanning beds, melanoma, ultraviolet radiation
Abbreviations used : arUVR, MPQ, OR, UV, UVR
Plan
| Funding sources: REDCap is supported by Clinical and Translational Science Award (grant no. UL1 TR000448), and Siteman Cancer Center is supported in part by a National Cancer Institute Cancer Center (grant no. P30 CA091842 to Dr Eberlein). |
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| Conflicts of interest: None disclosed. |
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| Reprints not available from the authors. |
Vol 79 - N° 6
P. 1101-1108 - décembre 2018 Retour au numéro
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