Relationship between vascular cell adhesion molecule-1 and morbidly adherent placenta - 10/11/18
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Highlights |
• | This is the first study on the role of adhesion molecules in MAP cases in the literature. |
• | We found that the expression of VCAM-1 was significantly higher in MAP cases. |
• | This study can bear a torch for the prediction and treatment in morbidly adherent placenta. |
Abstract |
Introduction |
Morbidly adherent placenta is a clinical condition of which prevalance is steadily increasing. It is described as the invasion of the placenta into the uterine wall through the myometrium and beyond. Vascular cell adhesion molecule-1 is a calcium independent transmembrane glycoprotein. Several studies have shown that vascular cell adhesion molecule-1 increases invasion in tumor cells. In our study we investigated the expression of vascular cell adhesion molecule-1 which has been shown to increase invasion in various tumors in morbidly adherent placenta cases.
Material and method |
This is a prospective case–control study. Eighty-four patients who were diagnosed with morbidly adherent placenta and 96 patients without any risk factors as a control group were included in the study. Vascular cell adhesion molecule-1 staining was examined by immune-histochemical staining in placental samples.
Results |
The patients included in the study were similar in terms of demographic characteristics. Of the 84 patients in the morbidly adherent placenta group, 65 (74.7%) showed positive staining. This number was 39 (40.6%) in the control group. Staining in morbidly adherent placenta group was statistically significantly higher (p<0.05).
Discussion |
The etiology of morbidly adherent placenta is still a clinically unknown condition. This study is the first study on this field in the literature. In our study, we showed that vascular cell adhesion molecule-1 expression increased in morbidly adherent placenta group. Although the entire pathogenesis is not explained this can be considered as a step for understanding this subject.
Le texte complet de cet article est disponible en PDF.Abbreviations : ICAM-1, MAP, PBS
Keywords : Adherent placenta, VCAM, Adhesion molecule, Invasion
Plan
Vol 47 - N° 10
P. 549-553 - décembre 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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