Biomedical applications of microemulsion through dermal and transdermal route - 13/11/18
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Graphical abstract |
The conventional topical formulations (like ointment, gel, cream, lotion, etc.) are not able to deliver the drug deep into the skin because of the presence of stratum corneum as skin barrier (3). Also, the subdermal injections are very painful and inconvenient approach of drug administration (1). In comparison to both of these, the microemulsion represents a novel drug carrier system to enhance the drug permeation across the skin and delivers the drug efficiently via transdermal route (2).
Abstract |
Microemulsions are thermodynamically stable, transparent, colloidal drug carrier system extensively used by the scientists for effective drug delivery across the skin. It is a spontaneous isotropic mixture of lipophilic and hydrophilic substances stabilized by suitable surfactant and co-surfactant. The easy fabrication, long-term stability, enhanced solubilization, biocompatibility, skin-friendly appearance and affinity for both the hydrophilic and lipophilic drug substances make it superior for skin drug delivery over the other carrier systems. The topical administration of most of the active compounds is impaired by limited skin permeability due to the presence of skin barriers. In this sequence, the microemulsion represents a cost-effective and convenient drug carrier system which successfully delivers the drug to and across the skin. In the present review work, we compiled various attempts made in last 20 years, utilizing the microemulsion for dermal and transdermal delivery of various drugs. The review emphasizes the potency of microemulsion for topical and transdermal drug delivery and its effect on drug permeability.
Le texte complet de cet article est disponible en PDF.Keywords : Microemulsion, Transdermal drug delivery, Skin barriers, Skin permeation, Bioavailability
Plan
Vol 108
P. 1477-1494 - décembre 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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