During diabetes oxidative stress in the lenses occurs.
Antioxidative enzymes activity in the rats’ lenses is altered by diabetes.
Changes in the oxidative stress markers levels in the lenses of the rats are noted.
Naringenin treatment counteracts changes in the antioxidative enzymes activity.
Naringenin mitigates the negative effect of diabetes on oxidative stress markers.
Oxidative stress arising during diabetes may lead to cataract formation. Thus, in order to prevent oxidative stress development, antioxidants could be considered helpful agents. Naringenin, a flavonoid with a well-documented antioxidative activity, can be found in many plant-derived products, especially citrus fruits. The aim of the study was to examine the effect of naringenin on oxidative stress markers in the lenses of type 1 diabetic rats. The study was conducted on 3-month-old male Wistar rats with streptozotocin-induced type 1 diabetes. The rats were treated orally with naringenin at the doses of 50 and 100 mg/kg for 4 weeks. In the lenses obtained from the animals, enzymatic and non-enzymatic parameters connected with oxidative stress were measured. The enzymatic parameters included superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase activity. For non-enzymatic parameters, the total thiol groups, reduced and oxidized glutathione, protein carbonyl groups, advanced oxidation protein products, malondialdehyde and vitamin C level were assayed. Oral administration of naringenin counteracted most of the unfavorable changes induced by diabetes, including reduction of elevated antioxidative enzymes activity and amelioration of oxidative damage in proteins and lipids. Naringenin administered orally reduces oxidative stress markers in the lenses of type 1 diabetic rats.Le texte complet de cet article est disponible en PDF.
Abbreviations : ALT, AOPP, AST, C, CAT, DM, G6PD, GGT, GSH, GPx, GR, GSSG, HDL-C, LDL-C, MDA, Nar50, Nar100, PCG, po, ROS, SOD, STZ, Tot-SH, VC
Keywords : Lenses, Naringenin, Oxidative stress, Rats, Diabetes
Vol 108P. 974-984 - décembre 2018 Retour au numéro
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