Metabolic impairments and tissue disorders in alloxan-induced diabetic rats are alleviated by Salvia officinalis L. essential oil - 13/11/18
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Graphical abstract |
Highlights |
• | Sage essential oil (EO) significantly inhibited in vitro α-amylase and lipase activities. |
• | Sage EO inhibited α-amylase and lipase activities in vivo at a dose 2.5 μL per diabetic rat. |
• | Sage EO remarkably reduced glycemia and increased glycogen storage in treated diabetic rats. |
• | Sage EO significantly lowered the ALT, AST and LDH activities after treatment of diabetic rats. |
• | Sections of liver, kidney and pancreas confirmed that the tested dose of Sage EO had no toxic effects. |
Abstract |
The current research explored for the first time the effect of Salvia officinalis L. (Sage) essential oil (EO) on Alloxan-induced diabetes in male Wistar rats. Sage EO was extracted by a Clevenger apparatus and analyzed by GC-FID and GC–MS. The most important chemical families identified in this oil were oxygenated monoterpenes (56.32%), hydrocarbon monoterpenes (15.00%) and hydrocarbon sesquiterpenes (14.70%). All treatments were administered orally. In vitro investigation showed that the EO had α-amylase and lipase inhibitory activities with IC50 = 38 μg/mL and IC50 = 52 μg/mL, respectively. In vivo experiments highlighted that the activities of serum α-amylase and lipase were reduced by 46.6% and 32.1%, respectively. Sage EO reduced glycemia by 60% and the level of glycogen stored in the liver by 43.7%. Treatments of diabetes with Sage EO significantly protected the liver function by lowering serum AST (35%), ALT (79%) and LDH (43%) activities. Furthermore, Sage EO was efficient to preserve the kidney function in diabetes by reverting back serum creatinine (47%) and UA (62.5%) concentrations to control values.
The obtained results altogether evidenced that Sage EO had hypoglycemic and anti-obesity effects and could be a valuable complement in future diabetes therapy.
Le texte complet de cet article est disponible en PDF.Abbreviations : Sage, EO, DM, T1DM, T2DM, STZ, WHO, IDF, HD, GC-FID, GC–MS, DMSO, CNPG3, 4-MU oleate, PI, IC50, bw, FBG, GLUT, BBM, BLM, SGLT, GK, AST, ALT, LDH, GFR, UA, SUA, PPAR-γ
Keywords : Salvia officinalis lamiaceae, Essential oil, Monoterpenes, Glycemia, Rat digestive key enzymes
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Vol 108
P. 985-995 - décembre 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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