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The outcome of electrostimulation associated with the tubulization technique after sciatic nerve transection in wistar rats - 25/11/18

Doi : 10.1016/j.hansur.2018.10.213 
T. Pitagoras , M.M. Campos, P. Chagastelles, E. Goldani, J. Braga Silva
 PUCRS, Porto Alegre, Brésil 

Auteur correspondant.

Résumé

Peripheral nerve injuries are common in clinical practice and are responsible for serious problems such as pain, loss of sensibility and motor, and permanent sequelae. The results of electrical stimulation are encouraging and suggest its use as an alternative treatment after nerve transaction.

Objective

To evaluate, in vivo, the use of electrostimulation (EE) associated with the tubulization technique on sciatic nerve injury repair in Wistar rats. Ninety male Wistar isogenic rats weighing between 200 and 300 grams were divided into three groups of 30 rats (electrostimulation associated with the tubing technique (EE), tubing suture (ST) and suture (SUT)), which were subdivided into three other groups with ten animals according to the evaluation time (three, six and nine weeks postoperative). Regeneration was assessed by walking track and histological analysis in which the determination of the area and number of Schwann cells in the nerve samples were carried out. In the functional evaluation, the group that received only one EE with 20Hz, 3V for one hour showed better result, statistically significant when compared to those stimulated more than once. However, when comparing the three different types of treatment at the end of nine weeks, there was statistically significant superiority in those ones treated with standard suture. Regarding the number of cells, no statistically significant result was found in none of the groups. The findings related to the nerve area, in those submitted to EE at three weeks when compared to the other groups in the same period, were significant, and in the comparison within the same group, those with suture and tube at six weeks obtained a regenerated nerve with area in a statistically significant way. The result of the functional recovery, when applied once to the EE with frequency of 20Hz and 3V, was similar with the studies already carried out, but the hypothesis that there would be an improvement of the results in the EE groups, with three and six weeks, was zero. Although the desired results in this study have not been obtained, it has been understood that the use of a biocompatible device for electrical stimulation of peripheral nerves and its methodology of use is an ongoing process that requires a balance between medicine and engineering and the subject must continue to be studied due to the promising results obtained so far.

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© 2018  Publié par Elsevier Masson SAS.
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Vol 37 - N° 6

P. 452 - décembre 2018 Retour au numéro
Article précédent Article précédent
  • Réflexion sur l’utilisation de la fraction vasculaire stromale dans la rhizarthrose
  • D. Coquerel-Béghin, A.C. Portenard, A. Bonmarchand, R. Carloni, I. Nseir, C. Giverne, I. Auquit-Auckbur
| Article suivant Article suivant
  • The use of adipose stem cells and the tubulization technique on regeneration of the facial nerve in wistar rats after transection with loss of substance
  • J. Poeta, M.M. Campos, P. Chagastelles, E. Goldani, J. Braga Silva

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