Comparison of effects of MHBFC on cardiac hypertrophy after banding of the abdominal aorta in wild-type mice and eNOS knockout mice - 09/12/18
pages | 12 |
Iconographies | 10 |
Vidéos | 0 |
Autres | 0 |
Graphical abstract |
Highlights |
• | MHBFC was a monomer extracting from Chinese traditional herbs by our research group. |
• | MHBFC is beneficial to protect against cardiac hypertrophy in wild-type mice. |
• | MHBFC could not induce any significant change in eNOS gene knockout mice. |
• | MHBFC depends on the existence of eNOS genes to reverse cardiac hypertrophy. |
Abstract |
17-Methoxyl-7-hydroxy-benzene-furanchalcone (MHBFC) was isolated from the Millettia pulchra (Benth.) Kurz var. Laxior (Dunn) Z. Wei (Papilionaceae) (MKL) roots. This study aimed to study the effects of MHBFC on cardiac hypertrophy after banding of the abdominal aorta in wild-type mice and endothelial nitric oxide synthase (eNOS) knockout mice in order to verify whether MHBFC depends on the eNOS gene in reversing cardiac hypertrophy. By observing the blood pressure, body weight, ventricular hypertrophy index, expression of B-type natriuretic peptide (BNP), myosin heavy chain beta (β-MHC), atrial natriuretic peptide (ANP), serum amyloid A SAA mRNA, level of endothelin-1 (ET-1) protein, histopathological changes of myocardial cells, and the myocardial ultrastructure, we found that MHBFC significantly ameliorated the changes in the structure of the heart and aorta, significantly decreased the blood pressure, myocardial cell cross-section area, level of ET-1 protein, and mRNA levels of BNP, β-MHC, ANP and SAA, prevented myocardial ultrastructure alterations, and relieved myocardial and perivascular fibrosis of wild-type mice. However, MHBFC could not induce any significant change in eNOS gene knockout mice. These results show that MHBFC is beneficial to protect against cardiac hypertrophy after banding of the abdominal aorta in wild-type mice, but has no such effect on eNOS gene knockout mice, which indicates that MHBFC is dependent on the existence of the eNOS gene in reversing cardiac hypertrophy.
Le texte complet de cet article est disponible en PDF.Keywords : Myocardial hypertrophy, MHBFC, eNOS knockout, Abdominal aortic banding
Plan
Vol 109
P. 1221-1232 - janvier 2019 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?