Low serum levels of CCL2 are associated with worse prognosis in patients with Acute Coronary Syndrome: 2-year survival analysis - 09/12/18
, Penélope Lacrísio dos Reis Menta a, Melissa Tainan Silva Dias a, Júlia Rodrigues Fraga a, Alessandra Carvalho Goulart b, Itamar Souza Santos b, c, Paulo Andrade Lotufo b, c, Isabela Martins Bensenor b, c, Jacqueline Isaura Alvarez-Leite aBienvenue sur EM-consulte, la référence des professionnels de santé.
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Highlights |
• | Acute Coronary Syndrome (ACS) and cardiac remodeling are associated with inflammation. |
• | CCL2 levels in 803 patients with ACS and the prognostic value of the chemokine were investigated. |
• | Low serum levels of CCL2 were associated with fatal or new non-fatal myocardial infarction. |
• | CCL2 may be useful as a prognostic factor in ACS. |
Abstract |
Inflammation is very important in Acute Coronary Syndrome (ACS) as well as in cardiac remodeling after an acute myocardial infarction (MI). Our study examined the prognostic value of Chemokine (C-C motif) ligand 2 (CCL2) in patients with ACS in the ERICO (Strategy of Registry of Acute Coronary Syndrome) study. We evaluated serum samples from 803 patients. The prognostic value of CCL2 was evaluated at the 2-year follow-up, according to cutoff points established by the median. Kaplan-Meier curves and Cox regression were used for analysis of all-cause mortality, cardiovascular mortality, and a combined outcome of fatal myocardial infarction or new non-fatal MI. There were 115 deaths from all causes, 78 deaths due to cardiovascular causes and 67 events in combined outcomes. CCL2 levels below the median (≤100.9 pg/mL) were associated with increased risk of MI death or new non-fatal MI, even after model adjustment. Low serum levels of CCL2 shows a significant association with fatal or new non-fatal MI.
Le texte complet de cet article est disponible en PDF.Abbreviations : ACS, AMI, BMI, CAD, CCL2, CI, ELISA, ERICO, HDL, HR, IL-1β, IL-10, LDL, MI, NSTEMI, STEMI, TGF-β, TNF, UA
Keywords : Acute Coronary Syndrome, CCL2, Coronary Artery Disease, Myocardial infarction, Prognosis
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Vol 109
P. 1411-1416 - janvier 2019 Retour au numéro
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