Mate tea reduces high fat diet-induced liver and metabolic disorders in mice - 09/12/18
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Graphical abstract |
Highlights |
• | Obesity is a global public health challenge. |
• | High fat diet can lead to liver steatosis. |
• | Consumption of mate tea is popular in Brazil. |
• | Mate tea consumption reduced liver steatosis in mice. |
Abstract |
High-fat diet (HFD)-induced obesity is a worldwide health problem and can cause lipid accumulation in the liver. We evaluated the hepatoprotective effect of mate tea treatment in mice submitted to an HFD. C57BL/6 mice were fed an HFD for 13 weeks with and without mate tea. A separate group of mice was treated with fenofibrate as a positive control (a regular drug for lipid disorders). Histological analyses, glucose tolerance tests (GTT), and quantification of mediators related to lipid peroxidation, oxidative stress and blood biomarkers for lipid profile were performed. The weight of animals and major organs related to hepatic steatosis was determined, and proinflammatory cytokines and the participation of the Nrf2 pathway and adiponectin were evaluated. Mate tea prevented the accumulation of lipid droplets in hepatocytes as well as weight gain in animals submitted to the HFD. Mate tea treatment also prevented increases in the liver weight, heart weight and amount of visceral and subcutaneous white adipose tissue. Mate tea was able to prevent the deregulation of glucose uptake, as evaluated by GTT, and improved the indicators of oxidative stress, such as nitrite levels, catalase activity, and oxidative damage, as evaluated by protein carbonylation and the MDA levels. Mate tea had an anti-inflammatory effect, preventing the increase of IL-1β and KC and upregulating the expression of Nrf2. Mate tea prevented insulin increase and HDL cholesterol decrease but did not affect total cholesterol or triglycerides levels. Treatment also prevented adiponectin increase. Mate tea may be a good resource to reduce hepatic steatosis in the future since it has anti-diabetic, anti-inflammatory and antioxidant effects, which prevent the accumulation of fat in the liver.
Le texte complet de cet article est disponible en PDF.Abbreviations : NAFLD, NASH, FFA, DM2, HFD, CTR, HFD + Mate, HFD + FFB, GTT, H&E, MDA, ELISA, H2O2, SDS-PAGE, PVDF, Nrf2, Keap1, ANOVA, vWAT, iWAT, AUC, IL-1β, IL-8, KC, HDL, ROS, TNF-α, IL-6
Keywords : Liver steatosis, Mate tea, Oxidative stress, Inflammation, Mouse
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Vol 109
P. 1547-1555 - janvier 2019 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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