Abolishment of fear memory-disruptive effects REM sleep deprivation by harmane - 09/12/18
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Graphical abstract |
Highlights |
• | Repeated administration of a subthreshold dose of harmane impaired fear memories. |
• | Stress did not alter harmane response on fear memory retention. |
• | REM sleep deprivation, prior to training, impaired fear memories. |
• | Harmane abolished fear memory deficits in REM sleep deprived mice during 24 h. |
• | Harmane modulates conditioned fear memory in REM sleep deprived-mice. |
Abstract |
Harmane, as a neuromodulator, implicates in the learning and memory processes. However, rapid eye movement (REM) sleep deprivation negatively affects these processes. Here, we investigated the effects of harmane (2.5 mg/kg) on the regulation of fear memory in free moving groups (FMG), large platform groups (LPG) and REM-deprived mice. We employed a flower pot technique for REM sleep deprivation and a Pavlovian fear conditioning paradigm for assessment of fear memories. FMGs received two or three pre-training intraperitoneal administrations of harmane at 12 h intervals, impaired contextual memory retention but those received three harmane administrations showed an auditory memory disruption. LPGs, with or without harmane, did not alter fear memories compared to their respective FMGs, indicating the inability of stress on fear responses of FMGs. Moreover, 12, 24 and 36 h REM sleep deprivation impaired contextual memory retrieval, while 24 and 36 h REM sleep deprivation impaired auditory fear memory retention. Furthermore, harmane only abolished contextual and auditory fear memory deficits induced by 24 h REM sleep deprivation. The data suggests a modulatory role for harmane in REM sleep deprivation response on fear memory.
Le texte complet de cet article est disponible en PDF.Keywords : Harmane, REM sleep deprivation, Conditioned fear memory, Mice
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Vol 109
P. 1563-1568 - janvier 2019 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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