FS-7 inhibits MGC-803 cells growth in vitro and in vivo via down-regulating glycolysis - 09/12/18
, Guotao Tang a, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Graphical abstract |
Highlights |
• | FS-7 had potent anticancer activity in human gastric carcinoma MGC-803 cell line. |
• | FS-7 had potent anticancer activity in vivo/vitro and was superior to 5-Fu. |
• | FS-7 down-regulated glycolysis-related protein HIF-1α, HK-II and PFKP. |
Abstract |
In this study, we investigated the anticancer effects of FS-7, a flavonoid salicylate derivative, in human gastric carcinoma MGC-803 cell line and studied its preliminary anticancer effects. FS-7 displayed greater in vitro cytotoxicity against MGC-803 cell line compared with 5-Fu and had a certain extent of selectivity to cancer cells. The flow cytometry analysis revealed that FS-7 induced apoptosis MGC-803 cells and mainly caused cells arrest in the G2/M phase in a concentration-dependent manner. Additionally, FS-7 inhibited the colony formation and cell migration in a concentration-dependent manner. Notably, FS-7 noticeably down-regulated glycolysis-related protein HIF-1α, HK-II and PFKP expression in a concentration-dependent manner, possibly causing glycolysis inhibition. Importantly, compared with 5-Fu, FS-7 showed better anticancer activity in the MGC-803 xenograft murine tumor models. Collectively, the present study provided a promising anticancer drug candidate for gastric cancer therapy.
Le texte complet de cet article est disponible en PDF.Keywords : FS-7, MGC-803, Anticancer, HIF-1α, Glycolysis
Plan
Vol 109
P. 1659-1669 - janvier 2019 Retour au numéro
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